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Endometrial Receptivity Analysis (ERA)

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Endometrial Receptivity Analysis (ERA)

Secret to Successful Pregnancy: ERA Test

Challenges with the endometrial lining stand as a prominent factor behind female infertility. The uterus is lined with a vital tissue known as the endometrium, which prepares itself monthly for potential embryo arrival. It is the very site where an embryo implants and thrives during pregnancy. However, when this process falters, menstruation commences, shedding the endometrial lining.

Understanding Endometrial Receptivity

In some cases, the implantation of the embryo into the endometrium encounters obstacles. Various factors can contribute to this, with endometrial receptivity playing a pivotal role. The endometrium is considered receptive when it is primed for embryo implantation. This phase of receptivity is known as the "window of implantation."

The ERA Test: A Revolutionary Approach

The ERA (Endometrial Receptivity Analysis) test marks a groundbreaking advancement in assessing endometrial receptivity, backed by published clinical effectiveness. Developed and patented by IGENOMIX R&D Department since 2009, after over a decade of intensive research, this diagnostic method enables the evaluation of a woman's endometrial receptivity status. Gynecologists can easily and swiftly conduct a biopsy in their consultation room.


Lab Sequencing Unveils the Truth

 Cutting-edge laboratory, the expression of 236 genes linked to endometrial receptivity undergoes thorough analysis. A specially designed computational predictor processes the obtained data, classifying the endometrium as either "Receptive" or "Non-Receptive." In the case of receptivity, the "window of implantation" (WOI) aligns with the biopsy day, indicating the optimal time for embryo implantation. Conversely, non-receptivity signals a displaced WOI. Based on the initial non-receptive result, the process may be repeated, confirming the ideal WOI. Transferring an embryo during this optimal window greatly enhances the chances of a successful pregnancy.

Key Advantages: Elevating Pregnancy Success Rates

ERA is a pivotal tool that has the potential to significantly boost global pregnancy rates, achieving success rates of up to 85%* when personalized transfers align with the test results.

Accessing ERA

For comprehensive information and to explore the ERA test's applicability to your case, consult your Gynecologist, who can provide further insights and guidance.

FAQ

ERA is a diagnostic test that analyzes the endometrial lining of the uterus to determine the most receptive time for embryo transfer in IVF or other fertility treatments.

ERA is typically recommended for couples who have experienced recurrent implantation failure during IVF cycles or for those whose embryos consistently fail to implant despite good embryo quality.

  • Endometrial sampling: A small sample of the endometrial lining is taken during a mock embryo transfer cycle.
  • Genetic analysis: The endometrial sample is analyzed to assess the expression of genes related to endometrial receptivity.
  • Receptivity window determination: The analysis helps identify the ideal timing for embryo transfer.

The endometrial sampling procedure is usually not painful, although some women may experience mild discomfort or cramping. It is typically performed without the need for anesthesia.

The success of ERA is not in achieving pregnancy on its own but in improving the timing of embryo transfer. By identifying the optimal window of receptivity, the chances of embryo implantation and pregnancy success can be significantly increased.

ERA is generally considered a low-risk procedure. The primary limitation is that it may not provide answers or solutions for all cases of implantation failure. Other factors affecting fertility and implantation, such as embryo quality and maternal health, need to be considered as well.

The cost of ERA can vary depending on the clinic, location, and individual circumstances. It's important to discuss the cost of ERA with your fertility clinic. In some cases, it may be covered by insurance, but coverage can vary widely.

If the ERA results indicate a deviation from the expected window of receptivity, the embryo transfer can be adjusted accordingly in future IVF cycles. This adjustment may involve changing the timing of progesterone administration or the embryo transfer.

ERA is not routinely used in all IVF or fertility treatments. It is typically recommended for cases of unexplained recurrent implantation failure, and the decision to undergo ERA should be made in consultation with your fertility specialist.

Yes, ERA can be repeated in subsequent cycles if necessary, particularly if the first analysis does not yield conclusive results or if there is a change in the treatment plan.

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