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PGS – Pre Implantation Genetic Screening

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PGS – Pre Implantation Genetic Screening

Unlocking the Future of Healthy Pregnancy: Preimplantation Genetic Screening (PGS)

we stand out as one of the few centers    offering Pre-Implantation Genetic Screening (PGS), a cutting-edge advancement in modern medicine. PGS empowers us to assess the genetic profile of embryos before implantation, enhancing the chances of a healthy pregnancy.

What Is Preimplantation Genetic Screening?

PGS allows for the genetic and chromosomal profiling of embryos before implantation. This technique helps identify defects or congenital diseases in embryos, ensuring that only the healthiest ones are selected for implantation. Unlike previous methods that could analyze only five out of the 23 chromosomes, PGS examines all 23, providing a comprehensive embryo profile. This approach offers a preferable alternative to post-conception diagnostic procedures that may lead to selective pregnancy termination if issues are identified.

PGS is presently the sole option to mitigate the high risk of having a child with a genetic disease before conception, offering an appealing solution for preventing heritable genetic disorders.

When Is PGS Performed in the Treatment Cycle?

PGS is a crucial step in the in vitro fertilization (IVF) cycle. After the egg retrieval, the sperm and eggs are combined to form embryos. Pre-Implantation Genetic Screening is conducted at this stage to analyze the embryo's genetic makeup. The healthiest embryo is then transferred into the woman's uterus through an Embryo Transfer procedure.

Who Benefits from PGS?

PGS is typically employed in cases of:

?       History of Miscarriages: It addresses recurrent miscarriages often caused by chromosome abnormalities.

?       Previous Pregnancy with Chromosome Abnormality: Reduces the risk of similar issues in future pregnancies.

?       Multiple Failed IVF Cycles: Enhances chances of healthy pregnancies by avoiding embryo transfer with chromosome abnormalities.

?       Balanced Structural Chromosome Rearrangements: Minimizes the risk of unbalanced chromosomes in offspring.

?       Autosomal Dominant Genetic Diseases (e.g., Marfan Syndrome): Prevents the inheritance of these conditions.

?       Recessive Genetic Diseases (e.g., Cystic Fibrosis Thalassemia, Sickle cell disease or color blindness): Reduces the risk of having offspring with such conditions.

PGD empowers couples with options for healthier pregnancies and lowered genetic disease risks.

Unique PGS Features:

?       Screening of all 23 chromosome pairs (unlike traditional methods).

?       Utilization of advanced micro-array technique (Array CGH).

?       Capability to perform both Blastomere and Trophectoderm biopsy based on screening stage.

?       Adherence to international standards with imported LASER and Micro-Manipulator equipment.

?       High-end Air Handling Unit in our IVF lab ensures a class 10,000 environment with positive airflow pressure.

Unlock the potential of a healthier pregnancy with PGS.

FAQ

PGS is a laboratory technique that involves analyzing a small number of cells from an embryo created through IVF to identify genetic abnormalities, such as aneuploidy (abnormal chromosome number). The purpose is to select embryos with the best chance of developing into a healthy pregnancy.

PGS is often recommended for couples with a history of genetic disorders, recurrent miscarriages, advanced maternal age, or those who have experienced multiple failed IVF cycles. It can also be used to improve the chances of a successful pregnancy for couples undergoing IVF.

The PGS process typically involves the following steps:
  • IVF procedure: The woman's eggs are retrieved and fertilized with sperm in a laboratory dish.
  • Embryo development: The embryos are allowed to grow for several days, typically to the blastocyst stage.
  • Biopsy: A small number of cells are removed from each embryo for genetic analysis.
  • Genetic screening: The genetic material of the biopsied cells is analyzed to identify any abnormalities.
  • Selection and transfer: Only embryos without identified genetic abnormalities are chosen for transfer into the woman's uterus.

The PGS procedure itself does not typically cause discomfort to the embryos. The biopsy is performed at a very early stage when the embryos are composed of only a few cells. Women may experience some mild cramping after the egg retrieval and embryo transfer, but this is usually not severe.

PGS can improve the chances of a successful pregnancy by selecting embryos without genetic abnormalities. However, success rates can vary based on individual circumstances and the age of the woman. It is essential to discuss potential benefits and limitations with a healthcare provider.

While PGS can reduce the risk of transferring embryos with genetic abnormalities, it is not a guarantee of a successful pregnancy. There is a risk of misdiagnosis, and not all genetic conditions can be screened for. Additionally, the biopsy procedure can pose a minimal risk to the embryos.

The cost of PGS varies widely by location and individual circumstances. It's important to discuss the cost of PGS with your fertility clinic. Many insurance plans do not cover the expense of PGS.

If all embryos are found to have genetic abnormalities, you and your healthcare provider may need to discuss other options, such as using donor eggs or sperm or exploring other fertility treatments.

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